CEP350

CEP350
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCEP350, CAP350, GM133, centrosomal protein 350
External IDsOMIM: 617870; MGI: 1921331; HomoloGene: 8879; GeneCards: CEP350; OMA:CEP350 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9857

74081

Ensembl

ENSG00000135837

ENSMUSG00000033671

UniProt

Q5VT06

E9Q309

RefSeq (mRNA)

NM_014810

NM_001039184

RefSeq (protein)

NP_055625

NP_001034273

Location (UCSC)Chr 1: 179.95 – 180.11 MbChr 1: 155.72 – 155.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.[5][6][7]

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.[8]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135837 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033671 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
  6. ^ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci. 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782.
  7. ^ a b "Entrez Gene: CEP350 centrosomal protein 350kDa".
  8. ^ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly". PLOS ONE. 3 (12) e3855. Bibcode:2008PLoSO...3.3855L. doi:10.1371/journal.pone.0003855. PMC 2586089. PMID 19052644.

Further reading


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