DOSEN PROFIL LENGKAP

PRRC2A
Identifiers
Aliases	PRRC2A, BAT2, D6S51, D6S51E, G2, proline rich coiled-coil 2A
External IDs	OMIM: 142580; MGI: 1915467; HomoloGene: 10567; GeneCards: PRRC2A; OMA:PRRC2A - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,637,771 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,383,873 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; ventricular zone; ; pituitary gland; ; anterior pituitary; ; right hemisphere of cerebellum; ; right frontal lobe; ; ganglionic eminence; ; prostate; ; left uterine tube;
	Top expressed in
	tail of embryo; ; ventricular zone; ; genital tubercle; ; superior frontal gyrus; ; lip; ; superior surface of tongue; ; gallbladder; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; neural layer of retina;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	extracellular exosome; membrane; nucleus; cytoplasm; nucleoplasm; cytosol; plasma membrane;
Biological process	cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	7916
	53761
ENSG00000204469; ENSG00000206427; ENSG00000231825; ENSG00000231370; ENSG00000226618;
	ENSG00000225164; ENSG00000225748
	ENSMUSG00000024393
	P48634
	Q7TSC1
	NM_004638; NM_080686
	NM_001199044; NM_020027
	NP_004629; NP_542417
	NP_001185973; NP_064411
	Wikidata
View/Edit Human	View/Edit Mouse

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene.^[5]^[6]^[7]

Function

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.^[7]

Interactions

BAT2 has been shown to interact with:

References

^ ^a ^b ^c ENSG00000206427, ENSG00000231825, ENSG00000231370, ENSG00000226618, ENSG00000225164, ENSG00000225748 GRCh38: Ensembl release 89: ENSG00000204469, ENSG00000206427, ENSG00000231825, ENSG00000231370, ENSG00000226618, ENSG00000225164, ENSG00000225748 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024393 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A. 87 (6): 2374–8. Bibcode:1990PNAS...87.2374B. doi:10.1073/pnas.87.6.2374. PMC 53689. PMID 2156268.
^ Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J, et al. (Jun 1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment". Nat Genet. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947. S2CID 33041319.
^ ^a ^b "Entrez Gene: BAT2 HLA-B associated transcript 2".
^ ^a ^b ^c ^d ^e ^f Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

External links

Human PRRC2A genome location and PRRC2A gene details page in the UCSC Genome Browser.

This protein-related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] ENSG00000206427, ENSG00000231825, ENSG00000231370, ENSG00000226618, ENSG00000225164, ENSG00000225748 GRCh38: Ensembl release 89: ENSG00000204469, ENSG00000206427, ENSG00000231825, ENSG00000231370, ENSG00000226618, ENSG00000225164, ENSG00000225748 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024393 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2156268-5] Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A. 87 (6): 2374–8. Bibcode:1990PNAS...87.2374B. doi:10.1073/pnas.87.6.2374. PMC 53689. PMID 2156268.

[pmid8499947-6] Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J, et al. (Jun 1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment". Nat Genet. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947. S2CID 33041319.

[entrez-7] "Entrez Gene: BAT2 HLA-B associated transcript 2".

[pmid14667819-8] ^ ^a ^b ^c ^d ^e ^f Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

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DOSEN PROFIL LENGKAP

BAT2

Function

Interactions

References

Further reading

External links

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