ABCC10

ABCC10
Identifiers
AliasesABCC10, EST182763, MRP7, SIMRP7, ATP binding cassette subfamily C member 10
External IDsOMIM: 612509; MGI: 2386976; HomoloGene: 58616; GeneCards: ABCC10; OMA:ABCC10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

89845

224814

Ensembl

ENSG00000124574

ENSMUSG00000032842

UniProt

Q5T3U5

Q8R4P9

RefSeq (mRNA)

NM_001198934
NM_033450
NM_001350518

NM_145140
NM_170680
NM_001347396

RefSeq (protein)

NP_001185863
NP_258261
NP_001337447

NP_001334325
NP_660122
NP_733780

Location (UCSC)Chr 6: 43.43 – 43.45 MbChr 17: 46.61 – 46.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.[5][6]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124574 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032842 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.
  6. ^ a b "Entrez Gene: ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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