Prokonvertin

Prokonvertin atau faktor VII (bahasa Inggris: proconvertin, Factor VII, FVII, F7, stable factor, serum prothrombin conversion accelerator, SPCA, autoprothrombin I, cofactor V, component B of prothrombin, cothromboplastin, kappa factor, precusor of serum prothrombin conversion accelerator, pro-SPCA, prothrombin conversion factor, prothrombin converting factor, prothrombin conversion accelerator II, proconvertinconvertin system, prothrombinogen, serozyme, stable factor) adalah sebuah enzim dari kelas serina protease yang meningkatkan laju konversi protrombin menjadi trombin dengan bantuan faktor III, IV dan V.[1] Gen dari prokonvertin terletak pada kromosom 13 (13q34). Prokonvertin diproduksi oleh hati dengan stimulasi vitamin K. Penggunaan warfarin dan zat anti koagulan lainnya dapat menurunkan fungsi prokonvertin.
Prokonvertin diketahui juga bereaksi dengan faktor III.[2][3]
Rujukan
- ^ (Inggris) "Factors". Farlex free dictionary. Diakses tanggal 2010-04-28.
- ^ Carlsson, Karin (2003). "Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor pathway inhibitor". Eur. J. Biochem. 270 (12). Germany: 2576–82. ISSN 0014-2956. PMID 12787023. ; ; ; ; Pemeliharaan CS1: Tahun (link)
- ^ Zhang, E (1999). "Structure of extracellular tissue factor complexed with factor VIIa inhibited with a BPTI mutant". J. Mol. Biol. 285 (5). ENGLAND: 2089–104. doi:10.1006/jmbi.1998.2452. ISSN 0022-2836. PMID 9925787. ; ; ; ; Pemeliharaan CS1: Tahun (link)
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