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Penghalang saluran klorida Penghalang saluran klorida adalah jenis obat yang menghambat transmisi ion (Cl−) melalui saluran klorida.
Asam niflumat adalah salah satu penghalang saluran klorida yang telah digunakan dalam penelitian ilmiah eksperimental.[1] Contoh lainnya adalah asam antrasena-9-karboksilat, penghalang saluran-klorida tipe-CLCN1 kuat yang ditemukan di otot rangka, yang digunakan untuk mempelajari model hewan myotonia congenita.[2]
Beberapa antagonis reseptor glisina dan reseptor GABAA juga bertindak sebagai penghalang saluran klorida.
Lihat pula
Referensi
Bacaan lebih lanjut
- Phillis JW, Song D, O'Regan MH (Januari 1998). "Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex". Brain Research. 780 (2): 352–5. doi:10.1016/S0006-8993(97)01352-8. PMID 9507191.
- Zhou, Yuhong; Shapiro, Michael; Dong, Qu; Louahed, Jamila; Weiss, Christine; Wan, Shanhong; Chen, Qiming; Dragwa, Carl; Savio, Dawn; Huang, Minxue; Fuller, Catherine; Tomer, Yaniv; Nicolaides, Nicholas C.; McLane, Michael; Levitt, Roy C. (2002). "A Calcium‐Activated Chloride Channel Blocker Inhibits Goblet Cell Metaplasia and Mucus Overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. 248. hlm. 150–170. doi:10.1002/0470860790.ch10. ISBN 9780470844786.
- Mohamed F, Senarathna L, Percy A, Abeyewardene M, Eaglesham G, Cheng R, Azher S, Hittarage A, Dissanayake W, Sheriff MH, Davies W, Buckley NA, Eddleston M (2004). "Acute human self-poisoning with the N-phenylpyrazole insecticide fipronil--a GABAA-gated chloride channel blocker". Journal of Toxicology. Clinical Toxicology. 42 (7): 955–63. doi:10.1081/CLT-200041784. PMC 1351141
 . PMID 15641641.
- Lukacs GL, Nanda A, Rotstein OD, Grinstein S (Agustus 1991). "The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells". FEBS Letters. 288 (1–2): 17–20. doi:10.1016/0014-5793(91)80992-C . PMID 1652470.
- Kang JX, Man SF, Brown NE, Labrecque PA, Clandinin MT (Agustus 1992). "The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells". The Biochemical Journal. 285 ( Pt 3) (3): 725–9. doi:10.1042/bj2850725. PMC 1132855 . PMID 1323271.
- Liu J, Lai ZF, Wang XD, Tokutomi N, Nishi K (April 1998). "Inhibition of sodium current by chloride channel blocker 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) in guinea pig cardiac ventricular cells". Journal of Cardiovascular Pharmacology. 31 (4): 558–67. doi:10.1097/00005344-199804000-00014 . PMID 9554805.
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