P53

Tumor suppressor p53 trimer + DNA fragment, Human.

p53 (bahasa Inggris: protein 53, p53) adalah faktor transkripsi yang mendapat julukan dalam bahasa Inggris sebagai "the guardian of the genome", atau "guardian angel gene", dan "master watchman" karena peran protein tersebut dalam menjaga sel dari mutasi genetik akibat kerusakan DNA.

p53 memiliki ekspresi yang beragam seperti berbagai fungsi seluler, regulasi, apoptosis, replikasi DNA, proliferasi, dll. Dalam kondisi normal, jumlah konsentrasi p53 dalam sitoplasma sangat sedikit dan hanya teraktivasi saat sel mengalami stress.[1]

Rendahnya asupan asam folat dan vitamin B6 dapat meningkatkan risiko mutasi genetik pada p53 dan menginduksi kanker usus besar.[2] Upregulasi p53 yang berlebihan, biasanya terjadi pada kasus kemoterapi kanker dengan penggunaan cisplatin, dapat meracuni ginjal, dan perlu diturunkan segera, misalnya dengan penggunaan pifithrin-α.[3]

Rujukan

Wikimedia Commons memiliki media mengenai Tumor suppressor protein p53.
  1. ^ (Inggris) "Watching the watcher: regulation of p53 by mitochondria". Graduate Center for Toxicology, University of Kentucky; Aaron K Holley dan Daret K St Clair. Diakses tanggal 2010-11-19.
  2. ^ (Inggris) "FOLATE AND VITAMIN B6 INTAKE AND RISK OF COLON CANCER IN RELATION TO P53 MUTATIONAL STATUS". Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Ludwig Boltzmann-Institute for Applied Cancer Research, KFJ-Spital, Vienna, Austria and Applied Cancer Research - Institute for Translational Research Vienna (ACR–ITR VIEnna), Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Department of Medical Oncology, Dana-Farber Cancer Institute; Eva S. Schernhammer, MD, DrPH, Shuji Ogino, MD, PhD, dan Charles S. Fuchs, MD, MPH. Diakses tanggal 2010-12-12.
  3. ^ (Inggris) "Activation and involvement of p53 in cisplatin-induced nephrotoxicity" (PDF). Department of Cellular Biology and Anatomy, Medical College of Georgia and Veterans Affairs Medical Center, Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Department of Internal Medicine, University of Arkansas for Medical Sciences; Qingqing Wei, Guie Dong, Tianxin Yang, Judit Megyesi, Peter M. Price, dan Zheng Dong. Diakses tanggal 2010-12-12.


Ikon rintisan

Artikel bertopik genetika ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.