IGK@
IGK@ (bahasa Inggris: Immunoglobulin kappa locus) adalah sebuah area pada kromosom 2 manusia yang mengandung gen untuk rantai ringan kappa (κ) sebuah antibodi atau immunoglobulin.[1] Pada manusia, rantai κ dikodikasikan dengan gen V (variable), J (joining) dan C (constant) pada daerah ini.[2] Semua gen tersebut akan mengalami rekombinasi V(D) untuk menghasilkan berbagai macam cadangan immunoglobulin.
Lokus Ig kappa terdiri dari sejumlah gen:
- IGKC: immunoglobulin kappa constant yang membungkus domain konstan dari rantai ringan kappa untuk kodikasi antibodi.[3]
- IGKJ@: immunoglobulin kappa joining group
- IGKJ1, IGKJ2, IGKJ3, IGKJ4, IGKJ5
- IGKV@: immunoglobulin kappa variable group
- IGKV1-5, IGKV1-6, IGKV1-8, IGKV1-9, IGKV1-12, IGKV1-16, IGKV1-17, IGKV1-27, IGKV1-33
- IGKV1D-8, IGKV1D-12, IGKV1D-13, IGKV1D-16, IGKV1D-17, IGKV1D-22, IGKV1D-27, IGKV1D-32, IGKV1D-33, IGKV1D-39, IGKV1D-43
- IGKV2-24, IGKV2-28, IGKV2-30, IGKV2-40
- IGKV2D-26, IGKV2D-28, IGKV2D-29, IGKV2D-30, IGKV2D-40
- IGKV3-11, IGKV3-15, IGKV3-20
- IGKV3D-7, IGKV3D-11, IGKV3D-20
- IGKV4-1
- IGKV5-2
- dan beberapa gen yang tidak berfungsi, serta gen semu (en:pseudogene).
Referensi
- ^ Criscitiello MF, Flajnik MF (2007). "Four primordial immunoglobulin light chain isotypes, including lambda and kappa, identified in the most primitive living jawed vertebrates". Eur. J. Immunol. 37 (10): 2683–94. doi:10.1002/eji.200737263. PMID 17899545.
- ^ Male, D., Brostoff, J., Roth, D.B., & Roitt, I. 2006. Immunology. 7th ed., Canada: Elsevier Limited
- ^ "Entrez Gene: IGKC immunoglobulin kappa constant".
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