Alprenolol

Alprenolol
Nama sistematis (IUPAC)
	(RS)-1-(2-alilfenoksi)-3-(isopropilamino)propan-2-ol
Data klinis
AHFS/Drugs.com	International Drug Names
Kat. kehamilan	?
Status hukum	?
Rute	Oral
Data farmakokinetik
Ikatan protein	80% - 90%
Waktu paruh	2-3 jam → 4-OH-alprenolol
Pengenal
Nomor CAS	13655-52-2
Kode ATC	C07AA01
PubChem	CID 2119
Ligan IUPHAR	563
DrugBank	DB00866
ChemSpider	2035
UNII	877K5MQ27W
KEGG	D07156
ChEBI	CHEBI:51211
ChEMBL	CHEMBL266195
Data kimia
Rumus	C15H23NO2
SMILES	eMolecules & PubChem
	InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3 ; Key:PAZJSJFMUHDSTF-UHFFFAOYSA-N ;

Alprenolol atau alfeprol adalah penyekat beta non-selektif serta antagonis reseptor 5-5-HT_1A dan 5-5-HT_1B,^[1] yang digunakan dalam pengobatan angina pektoris.^[2] Obat ini tidak lagi dipasarkan oleh AstraZeneca, tetapi mungkin masih tersedia dari perusahaan farmasi lain atau secara generik.

Referensi

^ Langlois M, Brémont B, Rousselle D, Gaudy F (1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". Eur. J. Pharmacol. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601.
^ Hickie JB (1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. doi:10.5694/j.1326-5377.1970.tb49984.x. PMID 4393977.

[pmid8093601-1] Langlois M, Brémont B, Rousselle D, Gaudy F (1993). "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". Eur. J. Pharmacol. 244 (1): 77–87. doi:10.1016/0922-4106(93)90061-d. PMID 8093601.

[pmid4393977-2] Hickie JB (1970). "Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial". Med. J. Aust. 2 (6): 268–72. doi:10.5694/j.1326-5377.1970.tb49984.x. PMID 4393977.

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